The spread for DHS sites (B) and RNA elements (D) are shown in the plots on the left. The inner dashed box indicates that parts of the plot have been magnified for the surrounding outer panels, although the scales in the outer plots provide the exact regions and dimensions magnified.
Panel A shows the spread over all non-exonic ENCODE elements greater than 2.5 kb from TSSs. In each case the vertical and horizontal cross hairs show representative levels for the neutral expectation for mammalian conservation and human population diversity respectively. Coding (C), UTR (U), genomic (G), intergenic (IG) and intronic (IN) averages are shown as filled squares. The top right corners have the strongest evolutionary constraint and lowest diversity. Each point is an average for a single dataset. Panel A shows the levels of pan-mammalian constraint (mean GERP score 24 mammals, x-axis) compared to diversity, a measure of negative selection in the human population (mean expected heterozygosity, inverted scale, y-axis) for ENCODE datasets.
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